Identifying clonidine-displacing substance

Identifying clonidine-displacing substance.

Clonidine-specific antisera recognize an endogenous clonidine-displacing substance in brain.

An endogenous substance in brain, clonidine-displacing substance, binds to the same receptor populations as clonidine and is biologically active. Since receptor binding sites can be modeled by using specific antiligand antibodies, we tested the hypothesis that polyclonal antibodies raised in rat and rabbit against the clonidine analog p-aminoclonidine coupled to hemocyanin would recognize compo...

Identifying substance use disorder in nursing.

Identifying and assessing the substance-exposed infant.

As the rate of opioid prescription grows, so does fetal exposure to opioids during pregnancy. With increasing fetal exposure to both prescription and nonprescription drugs, there has been a concurrent increase in identification of Neonatal Withdrawal Syndrome (NWS) and adaptation difficulties after birth. In addition, extended use of opioids, barbiturates, and benzodiazepines in neonatal intens...

Central role for nucleosomes in lupus.

properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors. A. Imidazoline-guanidinium receptive site in renal proximal tubule: asymmetric distribution, regulation by cations and interaction with an endogenous clonidine displacing substance.idazoxan label different populations of imidazoline sites on rat kidney.